Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenides

• Rémi Martinent,
• Javier López-Andarias,
• Dimitri Moreau,
• Yangyang Cheng,
• Naomi Sakai and
• Stefan Matile

Beilstein J. Org. Chem. 2020, 16, 2007–2016, doi:10.3762/bjoc.16.167

• for the thiol-mediated uptake, beginning with a dynamic covalent disulfide exchange with exofacial thiols, followed by either endocytosis or the direct crossing of membranes into cytosols through successive thiolate–disulfide exchange reactions or micellar pores (Figure 5b) [61]. Anionic glutamate was

A dynamic combinatorial library for biomimetic recognition of dipeptides in water

• Florian Klepel and
• Bart Jan Ravoo

Beilstein J. Org. Chem. 2020, 16, 1588–1595, doi:10.3762/bjoc.16.131

• ), while AA binds significantly weaker (K ≈ 65–71 M−1). Keywords: artificial receptor; dynamic combinatorial chemistry; dynamic covalent chemistry; molecular recognition; thiolate–disulfide exchange; Introduction Peptides are one of the most abundant and structurally versatile motifs in nature. Thus

• library to be under thermodynamic control. Therefore, the equilibrium responds to stimuli such as addition of a template, which would stabilize a suitable receptor and thus amplifies its formation. This strategy has led to the discovery of many artificial receptors [7][8][9][10], with thiolate disulfide

• exchange being one of the most prominent reactions [11][12][13][14]. Notably, while (pseudo)peptides are a common motif for DCL building blocks [7][11][15][16] very few DCLs use peptide templates. Still et al. showed early on that peptide receptors emerging from DCLs are possible. They screened for a